Bioassay of 4-chloro-o-toluidine hydrochloride for possible carcinogenicity
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Bioassay of 4-chloro-o-toluidine hydrochloride for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

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Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English

Subjects:

  • Carcinogens.,
  • Dyes and dyeing -- Toxicology.,
  • Toluidine blue -- Toxicology.

Book details:

Edition Notes

StatementCarcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
SeriesCarcinogenesis technical report series ; no. 165, DHEW publication ; no. (NIH) 79-1721, DHEW publication -- no. (NIH) 79-1721.
ContributionsNational Institutes of Health (U.S.).
The Physical Object
Paginationx, 104 p. :
Number of Pages104
ID Numbers
Open LibraryOL18014471M

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  A bioassay of 4-chloro-o-toluidine hydrochloride for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice. Groups of 50 rats of each sex were administered 4-chloro-o-toluidine in the diet at one of A bioassay for the possible carcinogenicity of 2-(chloromethyl)pyridine hydrochloride was conducted using Fischer rats and B6C3F1 mice. 2-(Chloromethyl)pyridine hydrochloride was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species, with the exception of 49 male rats in the high dose A bioassay of 4-chloro-o-toluidine hydrochloride for possible carcinogenicity was conducted by admin the test chemical in feed to F rats and B6C3F1 mice Groups of 50 rats of each sex were admin 4-chloro-o-toluidine in the diet at one of two doses, either 1, or 5, ppm, for wk. Groups of 50 mice of each sex were admin the test A rapid and specific analytical method has been developed for the monitoring of worker exposure to chlordimeform ().Residues of chlordimeform and metabolites in urine from field workers were hydrolyzed in a test tube under basic conditions to 4-chloro-o-toluidine which was partitioned into es of 4-chloro-o-toluidine in the organic phase were then analyzed using an automated HPLC

  4) National Cancer Institute (NCI). Bioassay of o-toluidine hydrochloride for possible carcinogenicity. National Can - cer Institute Carcinogenesis Technical Report Series ; 1― 5) Hecht SS, El-Bayoumy K, Rivenson A, et al. Compara-tive carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F :// Bentley P., Bieri F., Muecke W., Waechter F., Stäubli W. Species differences in the toxicity of p-chloro-o-toluidine to rats and nt binding to hepatic macromolecules and hepatic non-parenchymal cell DNA and an investigation of effects upon the incorporation of [3 H]thymidine into capillary endothelial -biol. :// A bioassay for the possible carcinogenicity of 5-chloro-o-toluidine was conducted using Fischer rats and B6C3F1 mice. 5-Chloro-o-toluidine was admin in the feed, at either of two concn, to groups of 50 male and 50 female animals of each :// Occupational exposure to ortho-toluidine can occur by inhalation or skin contact during its production, or during the production of dyes, pigments and rubber chemicals manufactured from this chemical. Laboratory and medical personnel may be exposed when using ortho-toluidine

Bioassay of o-toluidine hydrochloride for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.; Carcinogenesis Testing Program (U.S.); Frederick Cancer Research   Bioassay of 4-Chloro-o-toluidine Hydrochloride for Possible Carcinogenicity (CASRN ) Technical Report: TR PDF (3MB) Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CASRN ) Technical Report: TR PDF (5MB)   derivatives for long-term toxicity or carcinogenicity. J Environ Pathol Toxicol ; 2: 2) National Cancer Institute. Carcinogenesis bioassay of 4・ chloro-o・toluidine hydrochloride for. possible carcino­ genicity (CAS No. ・3) (Tech // Bioassay of o-toluidine hydrochloride for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.); Frederick Cancer Research Center. OCLC